- •The rate of return to high-level sports and clinical outcomes of revision anterior cruciate ligament reconstruction (ACLR) are inferior to primary ACLR.
- •Understanding anterior cruciate ligament (ACL) quantitative and radiographic anatomy and clinically relevant biomechanics is crucial for anatomic reconstructions and to improve clinical outcomes.
- •Revision ACLR are challenging and should be approached as a different entity than primary cases (they require a more detailed assessment of tibial slope, coronal plane alignment and tunnel malposition/osteolysis); hence, a proper diagnosis, failure cause assessment and planning is the cornerstone of patient success.
- •Revision ACLR are challenging and rely on addressing the cause of failure, and other potential relevant contributing factors would clarify this issue to improve patient outcomes.
- •Future prospective high-level studies would help to better elucidate clinical outcomes regarding single-stage versus two-stage revision ACLR, bone grafting technique, graft selection and alignment approach among other issues.
- •Further work using the proposed Failed ACLR Workup Algorithm should be done in order to improve clinical outcomes in this patient subset.
- •Improving return to high-level sports as well as decreasing the revision ACLR failure rates compared with primary cases will be a source of continuous research on this field.
Introduction
Anatomy and radiographic overview


Clinically relevant biomechanics
Isolated ACL biomechanical function
Secondary restraints in the ACL-deficient knee
Biomechanical effects of bone morphology
Aetiologies of ACLR failure

Clinical and radiographic examination of the failed ACLR

One-stage versus two-stage revision ACLR reconstruction procedure


Revision ACLR graft selection
Anterolateral complex reconstruction/repair
Discussion
Conclusions
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Contributors SP: planning and writing the manuscript. JDC: planning and writing the manuscript. GM: planning, writing and editing the manuscript. RL: planning, writing, editing and conducting of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests RL is Consultant for Arthrex, Ossur, Smith and Nephew and Linvatec. Receives royalties from Arthrex, Ossur and Smith and Nephew. Grants from Ossur and Smith and Nephew. Editorial boards of AJSM, KSSTA and JEO.
Patient consent for publication Not required.
Provenance and peer review Commissioned; externally peer reviewed.
Data availability statement All data relevant to the study are included in the article.
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